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STEROID 17-ALPHA-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 17-alpha-Hydroxylase
Descriptor
Spanish
:
Esteroide 17-alfa-Hidroxilasa
Descriptor
Portuguese
:
Esteroide 17-alfa-Hidroxilase
Synonyms
English
:
17 alpha-Hydroxylase
17,20-Lyase
CYP17
Cytochrome P-450(17 alpha)
P450(c17)
Steroid 17 alpha-Monooxygenase
Steroid 17-Hydroxylase
Steroid 17-Monooxygenase
Tree Number:
D08.244.453.915.748
D08.811.682.690.708.170.915.748
D08.811.682.690.708.783.745
D12.776.422.220.453.915.748
Definition
English
:
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of
progesterone
or
pregnenolone
and subsequent cleavage of the residual two carbons at C17 in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal
hyperplasia
(ADRENAL
HYPERPLASIA
, CONGENITAL) and abnormal sexual differentiation.
Entry Combination - descr/qualif
English
:
Steroid 17-alpha-Hydroxylase
/
deficiency
use
Adrenal Hyperplasia, Congenital
See Related
English
:
Adrenal Hyperplasia, Congenital
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23464
Unique Identifier:
D013254
Occurrence in VHL
:
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